Marine pollution bulletin, 2019-04, Vol.141, p.366-372
2019
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- Autor(en) / Beteiligte
- Titel
- Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
- Ist Teil von
- Marine pollution bulletin, 2019-04, Vol.141, p.366-372
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2019
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna perna. Levels of ethoxyresorufin‑O‑deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment. •Fluoxetine (FLX) occurs in seawater samples from Santos bay at 0.58 ng/L.•FLX induced Phase I and II enzymes in gills and digestive gland in mussels Perna perna.•Lipid peroxidation and DNA damage found in mussels gills exposed to 300 ng/L.•Environmentally relevant concentrations reduced the stability of haemocytes lysosomal membranes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0025-326XeISSN: 1879-3363DOI: 10.1016/j.marpolbul.2019.02.065Titel-ID: cdi_proquest_miscellaneous_2205414759
- Format
- –
- Schlagworte
- Antidepressants, Aquatic ecosystems, Bivalves, Brazil, Chemical analysis, Cholinesterase, Contaminants of emerging concern, Contamination, Damage assessment, Digestive glands, DNA, DNA damage, Ecosystems, Enzymatic activity, Enzyme activity, Fish, Fluoxetine, Freshwater, Freshwater organisms, Gills, Glutathione, Glutathione peroxidase, Glutathione transferase, Hemocytes, Inland water environment, Marine environment, Marine pollution, Metabolic response, Mollusks, Mussels, Perna perna, Peroxidase, Seawater, Stability, Stability analysis, Sublethal effects, Tropical climate, Tropical ecotoxicology, Water analysis