Details

Autor(en) / Beteiligte

• Tawfik, Kareem O.
• Klepper, Kristin
• Saliba, Joe
• Friedman, Rick A.

Titel

Advances in understanding of presbycusis

Ist Teil von

• Journal of neuroscience research, 2020-09, Vol.98 (9), p.1685-1697

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The pathophysiology of age‐related hearing loss (ARHL), or presbycusis, involves a complex interplay between environmental and genetic factors. The fundamental biomolecular mechanisms of ARHL have been well described, including the roles of membrane transport, reactive oxygen species, cochlear synaptopathy, vascular insults, hormones, and microRNA, to name a few. The genetic basis underlying these mechanisms remains under‐investigated and poorly understood. The emergence of genome‐wide association studies has allowed for the identification of specific groups of genes involved in ARHL. This review highlights recent advances in understanding of the pathogenesis of ARHL, the genetic basis underlying these processes and suggests future directions for research and potential therapeutic avenues.