Details

Autor(en) / Beteiligte

• Tokala, Ramya
• Bora, Darshana
• Sana, Sravani
• Nachtigall, Fabiane M
• Santos, Leonardo S
• Shankaraiah, Nagula

Titel

Ru(II)-Catalyzed Regioselective Hydroxymethylation of β‑Carbolines and Isoquinolines via C–H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening

Ist Teil von

• Journal of organic chemistry, 2019-05, Vol.84 (9), p.5504-5513

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A Ru­(II)-catalyzed regioselective C–H activation toward hydroxymethylation of β-carbolines and isoquinolines as effective directing groups has been developed, and the mechanism was probed by using online electrospray ionization-tandem mass spectrometry. The introduction of the hydroxymethyl group in the biologically relevant molecules routed via C–H functionalization remains an important task. Gratifyingly, this protocol draws attention to the regioselective formation of monohydroxymethylated β-carboline/isoquinoline products exclusively.