Future oncology (London, England), 2019-06, Vol.15 (17), p.2009-2018
2019
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- Autor(en) / Beteiligte
- Titel
- Overexpression of EIF5A2 in upper urinary tract urothelial carcinoma is a new independent prognostic marker of survival
- Ist Teil von
- Future oncology (London, England), 2019-06, Vol.15 (17), p.2009-2018
- Ort / Verlag
- England: Future Medicine Ltd
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To study the expression of EIF5A2 in urinary tract urothelial carcinoma and its clinicopathological features and prognosis. EIF5A2 expression was detected via immunohistochemistry in 101 patients. Kaplan-Meier analysis showed that the EIF5A2 low expression group had significantly longer overall survival (OS; p < 0.001) and progression-free survival (PFS; p < 0.001) than the EIF5A2 high expression group. The high expression of EIF5A2 significantly predict poor OS and PFS in the subset patients (p < 0.05). EIF5A2 was an independent prognostic factor for OS and PFS (p = 0.003 and p = 0.001). The established nomogram model and its calibration curve predicted the probability of survival accurately. EIF5A2 is a potential molecular marker of poor prognosis in urinary tract urothelial carcinoma.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1479-6694eISSN: 1744-8301DOI: 10.2217/fon-2018-0748Titel-ID: cdi_proquest_miscellaneous_2201718923
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Antigens, Biomarkers, Tumor, Bladder cancer, Carcinoma, Transitional Cell - mortality, Carcinoma, Transitional Cell - pathology, Carcinoma, Transitional Cell - surgery, Chinese medicine, Committees, EIF5A2, Eukaryotic Translation Initiation Factor 5A, Female, Females, Follow-Up Studies, Humans, Immunoglobulins, immunohistochemistry, Kaplan-Meier Estimate, Kidney Neoplasms - mortality, Kidney Neoplasms - pathology, Kidney Neoplasms - surgery, Kidney Pelvis - pathology, Kidney Pelvis - surgery, Lymphatic system, Male, Medical prognosis, Metastasis, Middle Aged, Nephroureterectomy, Nomograms, Ovarian cancer, Pathology, Patients, Peptide Initiation Factors - metabolism, Prognosis, Progression-Free Survival, RNA-Binding Proteins - metabolism, Surgery, Tumors, upper tract urothelial carcinoma, Ureter - pathology, Ureter - surgery, Ureteral Neoplasms - mortality, Ureteral Neoplasms - pathology, Ureteral Neoplasms - surgery, Urogenital system