Details

Autor(en) / Beteiligte

• Acar, Türker
• Kaya, Egemen
• Yoruk, Mustafa Deniz
• Duzenli, Neslihan
• Senturk, Recep Selim
• Can, Cenk
• Ozturk, Lokman
• Tomruk, Canberk
• Uyanikgil, Yigit
• Rybicki, Frank J.

Titel

Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents

Ist Teil von

• Japanese journal of radiology, 2019-06, Vol.37 (6), p.458-465

Ort / Verlag

Tokyo: Springer Japan

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents. Materials and methods The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N -Acetyl- l -cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically. Results Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 ( p  = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6. Conclusion Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.