Details

Autor(en) / Beteiligte

• Yang, Sen
• Zhu, Shuangyu
• Lu, Dengfu
• Gong, Yuefa

Titel

Formylation of Fluoroalkyl Imines through Visible-Light-Enabled H‑Atom Transfer Catalysis: Access to Fluorinated α‑Amino Aldehydes

Ist Teil von

• Organic letters, 2019-04, Vol.21 (7), p.2019-2024

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A visible-light-enabled catalytic formylation of fluoroalkyl imines is developed. With readily accessible starting materials and organocatalysts, this method provides a general approach to masked fluoroalkyl amino aldehydes. A synergistic catalytic effect between the photosensitizer and the H atom transfer agent was proven pivotal to this transformation. After removing the mask, free aldehydes can be obtained and further converted to various β-fluoroalkyl β-amino alcohols, which are attractive building blocks in the synthesis of bioactive and pharmaceutical compounds.