British journal of nutrition, 2019-04, Vol.121 (8), p.938-944
2019
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- Autor(en) / Beteiligte
- Titel
- Insulin-like growth factor I, binding proteins -1 and -3, risk of type 2 diabetes and macronutrient intakes in men
- Ist Teil von
- British journal of nutrition, 2019-04, Vol.121 (8), p.938-944
- Ort / Verlag
- Cambridge, UK: Cambridge University Press
- Erscheinungsjahr
- 2019
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The insulin-like growth factor (IGF) axis may be involved in the development of type 2 diabetes. We examined the associations of IGF-I and IGF binding proteins (IGFBP)-1 and -3 with diabetes risk and evaluated macronutrient intakes related to the observed associations. In a nested case–control study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers aged 50–69 years, the IGF variables were measured from baseline serum samples for a random sample of 310 men with diabetes diagnosed during a 12-year follow-up and for 310 controls matched by age, recruitment day and intervention group. Diet at baseline was assessed using a validated FFQ. The associations of IGF proteins with diabetes risk were estimated using conditional logistic regression and the associations with macronutrient intakes using linear regression. IGF-I and IGFBP-3 were not associated with the incidence of diabetes. Higher IGFBP-1 was associated with lower diabetes risk in an unadjusted crude model (OR 0·25; 95 % CI 0·15, 0·42 in the highest quartile compared with the lowest), but not after adjustment for BMI (corresponding OR 0·76; 95 % CI 0·41, 1·40). Intakes of carbohydrates, plant protein and milk protein associated positively and intake of meat protein and fat negatively with IGFBP-1 (P<0·005). IGFBP-1 was inversely associated with diabetes risk, but the association was substantially dependent on BMI. The associations between macronutrient intakes and IGFBP-1 may reflect influences of nutrients or foods on insulin concentrations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1145eISSN: 1475-2662DOI: 10.1017/S0007114519000321Titel-ID: cdi_proquest_miscellaneous_2196520552
- Format
- –
- Schlagworte
- Aged, alpha-Tocopherol - therapeutic use, beta Carotene - therapeutic use, Binding, Body Mass Index, Cancer, Carbohydrates, Carotene, Case-Control Studies, Diabetes, Diabetes mellitus, Diabetes mellitus (non-insulin dependent), Diabetes Mellitus, Type 2 - blood, Diabetes Mellitus, Type 2 - metabolism, Diet, Dietary fiber, Double-Blind Method, Epidemiolog to Epidemiology, Finland - epidemiology, Follow-Up Studies, Growth factors, Health risks, Humans, Insulin, Insulin resistance, Insulin-Like Growth Factor Binding Protein 1 - blood, Insulin-Like Growth Factor Binding Protein 3 - blood, Insulin-like growth factor I, Insulin-Like Growth Factor I - metabolism, Insulin-like growth factor-binding protein 1, Insulin-like growth factor-binding protein 3, Insulin-like growth factors, Laboratories, Male, Meat, Mens health, Middle Aged, Nutrients, Nutrients - blood, Primary Prevention, Proteins, Regression Analysis, Risk, Risk Factors, Smoking, Tocopherol, β-Carotene