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Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study
Ist Teil von
Digestive diseases and sciences, 2019-08, Vol.64 (8), p.2219-2230
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2019
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background and Aim
Helicobacter pylori
(
H. pylori
) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between
H. pylori
infection and metabolic syndrome in a Korean population.
Methods
Anthropometric and metabolic data, as well as anti-
H. pylori
IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.
Results
After excluding subjects with a history of
H. pylori
eradication therapy, or gastric symptoms, the seropositivity of
H. pylori
was 43.2% in 15,195 subjects.
H. pylori
-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (
P
< 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with
H. pylori
seropositivity. Finally, the prevalence of metabolic syndrome was higher in
H. pylori
-seropositive subjects than in negative ones (27.2% vs. 21.0%,
P
< 0.05), and
H. pylori
seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31,
P
< 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between
H. pylori
seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.
Conclusions
H. pylori
infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.