Details

Autor(en) / Beteiligte

• Petringa, G.
• Romano, F.
• Manti, L.
• Pandola, L.
• Attili, A.
• Cammarata, F.
• Cuttone, G.
• Forte, G.
• Manganaro, L.
• Pipek, J.
• Pisciotta, P.
• Russo, G.
• Cirrone, G.A.P.

Titel

Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations

Ist Teil von

• Physica medica, 2019-02, Vol.58, p.72-80

Ort / Verlag

Italy: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Monte Carlo approaches to calculate the Survival Fraction in clinical proton beam.•Computational method based to coupling Geant4 and LEM-III.•Computational method based to a parametrized approach.•Comparison with experimental data of two cell lines acquired at LNS-INFN. The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.