Details

Autor(en) / Beteiligte

• Ji, Xingyue
• Pan, Zhixiang
• Li, Chunjie
• Kang, Ting
• De La Cruz, Ladie Kimberly C
• Yang, Lingyun
• Yuan, Zhengnan
• Ke, Bowen
• Wang, Binghe

Titel

Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation

Ist Teil von

• Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3163-3168

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• A bottleneck for developing CO-based therapeutics is the lack of a safe and controllable delivery form. Herein, we describe efforts toward organic CO prodrugs with dual-responsive endogenous triggers. One representative CO prodrug showed significant anti-inflammatory effects both in vitro and in a LPS-simulated systemic inflammation model. These results firmly establish such CO prodrugs as either research tools or candidate compounds for the treatment of systemic inflammation or inflammation related organ injuries.