Details

Autor(en) / Beteiligte

• Ludwig, Daniel R.
• Fraum, Tyler J.
• Cannella, Roberto
• Ballard, David H.
• Tsai, Richard
• Naeem, Muhammad
• LeBlanc, Maverick
• Salter, Amber
• Tsung, Allan
• Shetty, Anup S.
• Borhani, Amir A.
• Furlan, Alessandro
• Fowler, Kathryn J.

Titel

Hepatocellular carcinoma (HCC) versus non-HCC: accuracy and reliability of Liver Imaging Reporting and Data System v2018

Ist Teil von

• Abdominal radiology (New York), 2019-06, Vol.44 (6), p.2116-2132

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2019

Link zum Volltext

Quelle

SpringerLink

Beschreibungen/Notizen

• Purpose The Liver Imaging Reporting and Data System (LI-RADS) was created to standardize the diagnostic criteria for hepatocellular carcinoma (HCC) and has undergone multiple revisions including a recent update in 2018 (v2018). The primary aim of this study was to determine the diagnostic performance and interrater reliability (IRR) of LI-RADS v2018 for distinguishing HCC from non-HCC primary hepatic malignancy in patients ‘at-risk’ for HCC. A secondary aim was to assess the impact of changes introduced in the v2018 diagnostic algorithm. Methods This retrospective study combined a 10-year experience of pathologically proven primary liver malignancies from two large liver transplant centers. Two blinded readers independently evaluated each lesion and assigned a LI-RADS diagnostic category, additionally scoring all relevant imaging features. Changes in category based on the reader-provided features and the new v2018 criteria were assessed by a study coordinator. Results The final study cohort comprised 105 HCCs and 73 non-HCC primarily liver malignancies. LI-RADS had a high specificity for distinguishing HCC from non-HCC (89% and 90% for reader 1 and reader 2, respectively), and IRR was moderate to substantial for final LI-RADS category and most features. Revision of the LI-RADS v2018 diagnostic algorithm resulted in very few changes [5 (2.8%) and 3 (1.7%) for reader 1 and reader 2, respectively] in overall lesion classification. Conclusion LI-RADS diagnostic categories and features had moderate to substantial IRR and high specificity for distinguishing HCC from non-HCC primary liver malignancy. Revision of LI-RADS v2018 diagnostic algorithm resulted in reclassification of very few lesions.