Details

Autor(en) / Beteiligte

• Olusanya, Temidayo O.B.
• Calabrese, Gianpiero
• Fatouros, Dimitrios G.
• Tsibouklis, John
• Smith, James R.

Titel

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Ist Teil von

• Biophysical chemistry, 2019-04, Vol.247, p.25-33

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2019

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT. [Display omitted] •Liposomes containing carborane for Boron Neutron Capture Therapy have been produced.•Liposomes have diameters of 80–100 nm, in the range for crossing the blood-brain-barrier.•Liposomes are stable in serum as reflected by retention experiments.