Details

Autor(en) / Beteiligte

• Liu, Han
• Lin, Shaoquan
• Jacobsen, Kristian M.
• Poulsen, Thomas B.

Titel

Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights

Ist Teil von

• Angewandte Chemie International Edition, 2019-09, Vol.58 (39), p.13630-13642

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A central goal of chemical biology is to develop molecular probes that enable fundamental studies of cellular systems. In the hierarchy of bioactive molecules, the so‐called ionophore class occupies an unflattering position in the lower branches, with typical labels being “non‐specific” and “toxic”. In fact, the mere possibility that a candidate molecule possesses “ionophore activity” typically prompts its removal from further studies; ionophores—from a chemical genetics perspective—are molecular outlaws. In stark contrast to this overall poor reputation of ionophores, synthetic chemistry owes some of its most amazing achievements to studies of ionophore natural products, in particular the carboxyl polyethers renowned for their intricate molecular structures. These compounds have for decades been academic battlegrounds where new synthetic methodology is tested and retrosynthetic tactics perfected. Herein, we review the most exciting recent advances in carboxyl polyether ionophore (CPI) synthesis and in addition discuss the burgeoning field of CPI chemical biology. Act‐ION: Exciting recent advances in the synthesis of carboxyl polyether ionophore natural products are reviewed. The primary focus is on studies directed at zincophorin and SCH‐351448 (see figure). In addition, recent insights concerning the cellular activities of selected CPIs are also discussed.