Details

Autor(en) / Beteiligte

• Colvin, Monica M
• Cook, Jennifer L
• Chang, Patricia P
• Hsu, Daphne T
• Kiernan, Michael S
• Kobashigawa, Jon A
• Lindenfeld, JoAnn
• Masri, S Carolina
• Miller, Dylan V
• Rodriguez, E Rene
• Tyan, Dolly B
• Zeevi, Adriana

Titel

Sensitization in Heart Transplantation: Emerging Knowledge: A Scientific Statement From the American Heart Association

Ist Teil von

• Circulation (New York, N.Y.), 2019-03, Vol.139 (12), p.e553-e578

Ort / Verlag

United States: by the American College of Cardiology Foundation and the American Heart Association, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate’s access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.