Details

Autor(en) / Beteiligte

• Margonis, Georgios A
• Kreis, Martin E
• Wolfgang, Christopher L
• Weiss, Matthew J

Titel

Mutation status and surgical selection

Ist Teil von

• Journal of surgical oncology, 2019-04, Vol.119 (5), p.616-622

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Current evidence cannot support denying metastasectomy in otherwise resectable patients solely based on their overall KRAS or BRAF mutational status. The combination of KRAS or BRAF mutational status with certain clinicopathologic characteristics has defined groups of patients who may not derive benefit from metastasectomy, but external validation is needed. The effect of certain KRAS or BRAF variants on survival may be more pronounced and therefore future studies should consider them for surgical selection.