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Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation
Ist Teil von
European journal of medicinal chemistry, 2019-04, Vol.167, p.105-123
Ort / Verlag
France: Elsevier Masson SAS
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
A series of aminothiazolyl norfloxacin analogues as a new type of potential antimicrobial agents were synthesized and screened for their antimicrobial activities. Most of the prepared compounds exhibited excellent inhibitory efficiencies. Especially, norfloxacin analogue II-c displayed superior antimicrobial activities against K. pneumoniae and C. albicans with MIC values of 0.005 and 0.010 mM to reference drugs, respectively. This compound not only showed broad antimicrobial spectrum, rapid bactericidal efficacy and strong enzymes inhibitory potency including DNA gyrase and chitin synthase (CHS), low toxicity against mammalian cells and no obvious propensity to trigger the development of bacterial resistance, but also exerted efficient membrane permeability, and could effectively intercalate into K. pneumoniae DNA to form a steady supramolecular complex, which might block DNA replication to exhibit their powerful antimicrobial activity. Quantum chemical studies were also performed to explain the high antimicrobial activities. Molecular docking showed that compound II-c could bind with gyrase–DNA and topoisomerase IV–DNA through hydrogen bonds and π-π stacking.
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•Novel aminothiazolyl norfloxacin analogues with broad antimicrobial spectrum were developed.•Compound II-c displayed low MIC values of 0.005 and 0.010 mM against K. pneumoniae and C. albicans.•Compound II-c showed strong enzyme inhibition, low toxicity and slow development of resistance.•Molecule II-c could bind with DNA gyrase and topoisomerase IV via hydrogen bonds and π-π stacking.•Compound II-c could intercalate DNA and disturb the K. pneumoniae membrane.