Details

Autor(en) / Beteiligte

• McKenna, Ronan
• Joseph, Lindsay
• Sargent, Philip
• May, Meryta
• Tozer, Sarah
• Bialasiewicz, Seweryn
• Heney, Claire
• Schlapbach, Luregn J
• Clark, Julia E

Titel

Paediatric intensive care admissions during the 2015–2016 Queensland human parechovirus outbreak

Ist Teil von

• Journal of paediatrics and child health, 2019-08, Vol.55 (8), p.968-974

Ort / Verlag

Australia: John Wiley & Sons Australia, Ltd

Erscheinungsjahr

2019

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Aim The human parechovirus (HPeV) has emerged as a pathogen causing sepsis‐like presentations in young infants, but there is a lack of data on HPeV presentations requiring intensive care support. We aimed to characterise the clinical presentation, disease severity, management and outcome of a population‐based cohort of children with microbiologically confirmed HPeV infection requiring admission to paediatric intensive care units (PICUs) in Queensland, Australia during a recent outbreak. Methods This was a multicentre retrospective study of children admitted to PICU between 1 January 2015 and 31 December 2016 with confirmed HPeV infection. Results Thirty infants (median age 20 days) with HPeV genotype 3 were admitted to PICU, representing 16% of all children with HPeV admitted to hospital and 6.4% of non‐elective PICU admissions in children <1 year of age. Children requiring PICU admission were younger than children admitted to hospital (P = 0.001). Apnoea, haemodynamic instability with tachycardia and seizures represented the main reasons for PICU admission. Eleven children (37%) required mechanical ventilation for a median duration of 62 h, 22 (73%) received fluid boluses and 7 (23%) were treated with vasoactive agents for a median duration of 53 h. Median length of stay was 2.62 days. A total of 24 children (80%) fulfilled sepsis criteria, 14 (47%) severe sepsis and 7 (23%) septic shock criteria. Eight (27%) had abnormal brain magnetic resonance imaging. No patient died. Conclusions We confirm that HPeV infection is an important cause of sepsis‐like syndrome in infants with substantial associated morbidity. Optimal management and long‐term outcomes require further investigation.