Details

Autor(en) / Beteiligte

• Yip, Rowena
• Ma, Teng
• Flores, Raja M.
• Yankelevitz, David
• Henschke, Claudia I.
• Yankelevitz, David F.
• Salvatore, Mary
• Flores, Raja
• Wolf, Andrea
• Chen, Mildred
• Libby, Daniel M.
• Smith, James P.
• Pasmantier, Mark
• Reeves, A.P.
• Markowitz, Steven
• Miller, Albert
• Deval, Jose Cervera
• Roberts, Heidi
• Patsios, Demetris
• Sone, Shusuke
• Hanaoka, Takaomi
• Zulueta, Javier
• de-Torres, Juan P.
• Lozano, Maria D.
• Aye, Ralph
• Manning, Kristin
• Bauer, Thomas
• Canitano, Stefano
• Giunta, Salvatore
• Cole, Enser
• Klingler, Karl
• Austin, John H.M.
• Pearson, Gregory D.N.
• Shaham, Dorith
• Aylesworth, Cheryl
• Meyers, Patrick
• Andaz, Shahriyour
• Vafai, Davood
• Naidich, David
• McGuinness, Georgeann
• Sheppard, Barry
• Rifkin, Matthew
• Thorsen, M. Kristin
• Hansen, Richard
• Kopel, Samuel
• Mayfield, William
• Luedke, Dan
• Klippenstein, Donald
• Litwin, Alan
• Loud, Peter A.
• Kohman, Leslie J.
• Scalzetti, Ernest M.
• Thurer, Richard
• Villamizar, Nestor
• Khan, Arfa
• Shah, Rakesh
• Liu, Xueguo
• Herzog, Gary
• Yeh, Diana
• Wu, Ning
• Lowry, Joseph
• Frumiento, Carmine
• Mendelson, David S.
• Smith, Michael V.
• Korst, Robert
• Taylor, Jana
• Ginsberg, Michelle S.
• Straznicka, Michaela
• Widmann, Mark
• Cecchi, Gary
• Matalon, Terence A.S.
• Scheinberg, Paul
• Odzer, Shari-Lynn
• Olsen, David
• Grannis, Fred
• Rotter, Arnold
• Ray, Daniel
• Mullen, David
• Wiernik, Peter H.
• Cheung, Edson H.
• Lim, Melissa
• DeCunzo, Louis
• Glassberg, Robert
• Pass, Harvey
• Endress, Carmen
• Yoder, Mark
• Shah, Palmi
• Welch, Laura
• Kalafer, Michael
• Green, Jeremy
• Walsh, James
• Bertsch, David
• Camacho, Elmer
• Chin, Cynthia
• O’Brien, James
• Willey, James C.

Titel

Survival with Parenchymal and Pleural Invasion of Non–Small Cell Lung Cancers Less than 30 mm

Ist Teil von

• Journal of thoracic oncology, 2019-05, Vol.14 (5), p.890-902

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• To determine long-term survival of visceral pleural invasion (VPI) and parenchymal invasion (PAI) (angiolymphatic and/or vascular) on survival of NSCLCs less than 30 mm in maximum diameter. Kaplan-Meier survivals for NSCLCs, with and without VPI and/or PAI, were determined for a prospective cohort of screening participants stratified by pathologic tumor size (≤10 mm, 11–20 mm, and 21–30 mm) and nodule consistency. Log-rank test statistics were calculated. The frequency of PAI versus VPI was significantly lower in patients with subsolid nodules than in those with solid nodules (4.9% versus 27.7% [p < 0.0001]), and correspondingly, Kaplan-Meier lung cancer survival was significantly higher among patients with subsolid nodules (99.1% versus 91.3% [p = 0.0009]). Multivariable Cox regression found that only tumor diameter (adjusted hazard ratio [HR] =1.07, 95% confidence interval [CI]: 1.01–1.14, p = 0.02) and PAI (adjusted HR = 3.15, 95% CI: 1.25–7.90, p = 0.01) remained significant, whereas VPI was not significant (p = 0.15). When clinical and computed tomography findings were included with the pathologic findings, Cox regression showed that the risk of dying of lung cancer increased 10-fold (HR = 10.06, 95% CI: 1.35–75.30) for NSCLCs in patients with solid nodules and more than twofold (by a factor of 2.27) in patients with moderate to severe emphysema (HR = 2.27, 95% CI: 1.01–5.11), as well as with increasing tumor diameter (HR = 1.06, 95% CI: 1.01–1.13), whereas PAI was no longer significant (p = 0.19). Nodule consistency on computed tomography was a more significant prognostic indicator than either PAI or VPI. We propose that patients with NSCLC with VPI and a maximum tumor diameter of 30 mm or less not be upstaged to T2 without further large, multicenter studies of NSCLCs, stratified by the new T status and that classification be considered separately for patients with subsolid or solid nodules.