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Effect of calcium phosphate phases affecting the crosstalk between osteoblasts and osteoclasts in vitro
Journal of biomedical materials research. Part A, 2019-05, Vol.107 (5), p.1001-1013
Shiwaku, Yukari
Tsuchiya, Kaori
Xiao, Linghao
Suzuki, Osamu
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Shiwaku, Yukari
Tsuchiya, Kaori
Xiao, Linghao
Suzuki, Osamu
Titel
Effect of calcium phosphate phases affecting the crosstalk between osteoblasts and osteoclasts in vitro
Ist Teil von
Journal of biomedical materials research. Part A, 2019-05, Vol.107 (5), p.1001-1013
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Previous studies have reported that octacalcium phosphate (OCP) enhances osteoblast differentiation and osteoclast formation during the hydrolysis process to hydroxyapatite (HA). However, the crystal phases that affect the crosstalk between osteoclasts and osteoblasts are unknown, which should determine the bone substitute material's property of OCP. The present study was designed to investigate whether the chemical composition and crystal structure of calcium phosphates affect osteoclast formation and the osteoclast–osteoblast crosstalk. Biodegradable β‐tricalcium phosphate (β‐TCP) was used as the control material. Osteoclasts were cultured on HA/OCP or HA/TCP disks and their cellular responses were assessed. Both OCP and β‐TCP had a similar ability to create multinucleated osteoclasts. However, OCP promoted the expression of complement component 3a (C3a), a positive coupling factor, in osteoclasts, whereas β‐TCP enhanced that of EphrinB2 (EfnB2) and collagen triple helix repeat containing 1 (Cthrc1). During osteoclast culture, phosphate ions were released from the crystals, and OCP‐HA conversion was advanced in HA/OCP mixtures and OCP. X‐ray diffraction analysis revealed no remarkable changes in the crystal structures of HA/TCP mixtures and β‐TCP before and after osteoclast culture. These results indicate that the distinct chemical environment induced by the calcium phosphate phases affects the crosstalk between osteoclasts and osteoblasts. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1001–1013, 2019.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.36626
Titel-ID: cdi_proquest_miscellaneous_2179415116
Format
–
Schlagworte
Biocompatibility
,
Biodegradability
,
Biodegradation
,
Biomedical materials
,
Calcium
,
Calcium phosphates
,
Cell culture
,
Chemical composition
,
Collagen
,
Complement component C3a
,
Crosstalk
,
Crystal structure
,
Crystals
,
Disks
,
Hydroxyapatite
,
Materials substitution
,
Octacalcium phosphate
,
Organic chemistry
,
Osteoblastogenesis
,
Osteoblasts
,
Osteoclastogenesis
,
Osteoclasts
,
osteoclast–osteoblast crosstalk
,
Phases
,
Substitute bone
,
Surgical implants
,
Tricalcium phosphate
,
X-ray diffraction
,
β‐tricalcium phosphate
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