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BibTeX
MicroRNAs control eyelid development through regulating Wnt signaling
Developmental dynamics, 2019-03, Vol.248 (3), p.201-210
Nagai, Takahiro
Trakanant, Supaluk
Kawasaki, Maiko
Kawasaki, Katsushige
Yamada, Yurie
Watanabe, Momoko
Blackburn, James
Otsuka‐Tanaka, Yoko
Hishinuma, Mitsue
Kitatmura, Atsushi
Meguro, Fumiya
Yamada, Akane
Kodama, Yasumitsu
Maeda, Takeyasu
Zhou, Qiliang
Saijo, Yasuo
Yasue, Akihiro
Sharpe, Paul T.
Hindges, Robert
Takagi, Ritsuo
Ohazama, Atsushi
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Nagai, Takahiro
Trakanant, Supaluk
Kawasaki, Maiko
Kawasaki, Katsushige
Yamada, Yurie
Watanabe, Momoko
Blackburn, James
Otsuka‐Tanaka, Yoko
Hishinuma, Mitsue
Kitatmura, Atsushi
Meguro, Fumiya
Yamada, Akane
Kodama, Yasumitsu
Maeda, Takeyasu
Zhou, Qiliang
Saijo, Yasuo
Yasue, Akihiro
Sharpe, Paul T.
Hindges, Robert
Takagi, Ritsuo
Ohazama, Atsushi
Titel
MicroRNAs control eyelid development through regulating Wnt signaling
Ist Teil von
Developmental dynamics, 2019-03, Vol.248 (3), p.201-210
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Background: The timing, location, and level of gene expression are crucial for normal organ development, because morphogenesis requires strict genetic control. MicroRNAs (miRNAs) are noncoding small single‐stranded RNAs that play a critical role in regulating gene expression level. Although miRNAs are known to be involved in many biological events, the role of miRNAs in organogenesis is not fully understood. Mammalian eyelids fuse and separate during development and growth. In mice, failure of this process results in the eye‐open at birth (EOB) phenotype. Results: It has been shown that conditional deletion of mesenchymal Dicer (an essential protein for miRNA processing; Dicer fl/fl;Wnt1Cre) leads to the EOB phenotype with full penetrance. Here, we identified that the up‐regulation of Wnt signaling resulted in the EOB phenotype in Dicer mutants. Down‐regulation of Fgf signaling observed in Dicer mutants was caused by an inverse relationship between Fgf and Wnt signaling. Shh and Bmp signaling were down‐regulated as the secondary effects in Dicer fl/fl;Wnt1Cre mice. Wnt, Shh, and Fgf signaling were also found to mediate the epithelial–mesenchymal interactions in eyelid development.Conclusions: miRNAs control eyelid development through Wnt. Developmental Dynamics 248:201‐210, 2019. © 2019 Wiley Periodicals, Inc. Key Findings miRNAs control eyelid development through Wnt signaling.
Sprache
Englisch
Identifikatoren
ISSN: 1058-8388
eISSN: 1097-0177
DOI: 10.1002/dvdy.10
Titel-ID: cdi_proquest_miscellaneous_2179381108
Format
–
Schlagworte
Animals
,
Bmp
,
Control
,
DEAD-box RNA Helicases - deficiency
,
dicer
,
Embryos
,
Eyelid
,
eyelid development
,
Eyelids - growth & development
,
Fgf
,
Gene expression
,
Gene Expression Regulation, Developmental
,
Genetic control
,
Genotype & phenotype
,
Mesenchyme
,
Mice
,
microRNA
,
MicroRNAs
,
MicroRNAs - physiology
,
miRNA
,
Morphogenesis
,
Organogenesis
,
Phenotype
,
Phenotypes
,
Proteins
,
Ribonuclease III - deficiency
,
Ribonucleic acid
,
RNA
,
Shh
,
Signaling
,
Wnt
,
Wnt protein
,
Wnt Signaling Pathway
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