Details

Autor(en) / Beteiligte

• Carruthers, Sean P.
• Cropley, Vanessa
• Bousman, Chad
• Everall, Ian P.
• Neill, Erica
• Pantelis, Christos
• Sumner, Philip J.
• Tan, Eric J.
• Bozaoglu, Kiymet
• Thomas, Elizabeth H.X.
• Van Rheenen, Tamsyn E.
• Gurvich, Caroline T.
• Rossell, Susan L.

Titel

The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders

Ist Teil von

• Psychiatry research, 2019-03, Vol.273, p.178-180

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• •rs2067477 variation has been linked to executive dysfunction in schizophrenia.•Executive function in schizophrenia spectrum was unaffected by rs2067477.•Non-executive cognition was also unaffected by rs2067477. Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test (WCST). We investigated if rs2067477 genotype variation influenced WCST performance and non-executive cognition cross-diagnostically in a sample of 147 schizophrenia spectrum participants (SSD) and 294 healthy controls. We were unable to detect any significant differences in executive and non-executive cognitive performance across genotype. A broader genetic focus should be considered when investigating the association between the muscarinic system and cognition in SSD.