Details

Autor(en) / Beteiligte

• Randall, Deborah A
• Bowen, Jennifer R
• Patterson, Jillian A
• Irving, David O
• Hirani, Rena
• Ford, Jane B

Titel

Mortality and hospital readmissions in the first year of life after intra‐uterine and neonatal blood product transfusions: A population data linkage study

Ist Teil von

• Journal of paediatrics and child health, 2019-10, Vol.55 (10), p.1201-1208

Ort / Verlag

Australia: John Wiley & Sons Australia, Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Aim Blood product transfusions are a potentially life‐saving therapy for fetal and neonatal anaemia, but there is limited population‐based research on outcomes. We aimed to describe mortality, readmission and average hospital stay in the first year of life for infants with or without intra‐uterine or neonatal blood product transfusions. Methods Linked birth, hospital and deaths data from New South Wales, Australia (January 2002–June 2014) were used to identify singleton infants (≥23 weeks' gestation, surviving to 29 days; n = 1 089 750) with intra‐uterine or neonatal transfusion or no transfusion. Rates of mortality and readmission in the first year (29–365 days) and days in hospital were calculated. Results Overall, 68 (0.06/1000) infants had experienced intra‐uterine transfusion and 4332 (3.98/1000) neonatal transfusion. Transfusion was more common among those born at earlier gestational ages requiring invasive ventilation. Mortality, readmissions and average days in hospital were higher among transfused than non‐transfused infants. Over half of infants with intra‐uterine and neonatal transfusion had ≥1 readmission in the first 29–365 days (55.9 and 51.8%, respectively), and around a quarter had ≥2 (20.6 and 28.5%, respectively) compared with 15.3% with ≥1 and 3.5% with ≥2 in the non‐transfused group. Conclusion Infants with a history of blood product transfusion, particularly those needing a neonatal transfusion, had higher mortality and more frequent contact with the hospital system in the first year of life than those infants with no history of transfusion.