Details

Autor(en) / Beteiligte

• Bär, Christian
• Thum, Thomas
• Gonzalo-Calvo, David de

Titel

Circulating miRNAs as mediators in cell-to-cell communication

Ist Teil von

• Epigenomics, 2019-02, Vol.11 (2), p.111-113

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Since their discovery in the blood circulation in 2008 (1), miRNAs have emerged as the subclass of the noncoding RNA superfamily that has gained most attention in biomarker development. [...]extracellular miRNAs secreted by donor cells could be delivered into recipient cells where they function as endogenous miRNAs leading to altered gene expression. The association between nonrandom circulating miRNA signatures with a wide array of cardiovascular conditions observed in patient-based studies suggests that circulating miRNAs are actively and selectively released from cells in response to stress or injury (10). [...]it is entirely conceivable that circulating miRNAs can function as signaling molecules in cardiovascular health and disease. Assuming a 1:1 stoichiometry between miRNAs and their mRNA targets may be an oversimplification. Since the bioinformatics tools available to explore this hypothesis have strong limitations (15), currently, this analysis is virtually impossible.