Neurological research (New York), 2019-04, Vol.41 (4), p.341-353
2019
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- Autor(en) / Beteiligte
- Titel
- The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice
- Ist Teil von
- Neurological research (New York), 2019-04, Vol.41 (4), p.341-353
- Ort / Verlag
- England: Taylor & Francis
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Low dietary iron load caused more pronounced abnormalities than high iron load in ob/ob mice. Discussion: Our data suggest that dietary non-heme iron deficiency may be a modulating factor in the pathogenesis of peripheral neuropathy in obese ob/ob mice with metabolic syndrome. Once the mechanisms can be further elucidated, how low dietary iron augments peripheral nerve degeneration and dysfunction via pro-inflammatory pathways and new therapeutic strategies could be developed. Abbreviations: CMAP: compound muscle action potential; cSNCV: compound sensory nerve conduction velocity; IENFD: intraepidermal nerve fiber density; LDL: low-density lipoprotein; MetS: metabolic syndrome; MNCV: motor conduction velocity; NCV: nerve conduction velocity; PN: peripheral neuropathy; PNS: peripheral nervous system; STZ: streptozotocin; T2D: type 2 diabetes mellitus; TNF alpha: tumor necrosis factor alpha; WHO: World Health Organization
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0161-6412eISSN: 1743-1328DOI: 10.1080/01616412.2018.1564191Titel-ID: cdi_proquest_miscellaneous_2179356842
- Format
- –
- Schlagworte
- Animals, Calcium-Binding Proteins - metabolism, Cytokines - metabolism, Diabetic Neuropathies - complications, Diabetic Neuropathies - diet therapy, Disease Models, Animal, iron, Iron, Dietary - therapeutic use, Leptin - deficiency, Leptin - genetics, Male, metabolic syndrome, Mice, Mice, Mutant Strains, Microfilament Proteins - metabolism, Microscopy, Electron, Transmission, Nerve Fibers - drug effects, Nerve Fibers - physiology, nerve inflammation, Nerve Tissue Proteins - metabolism, Neural Conduction - genetics, Neurogenic Inflammation - etiology, ob/ob mice, Peripheral neuropathy, Sciatic Nerve - pathology, Sciatic Nerve - ultrastructure, Skin - innervation, Skin - pathology