Details

Autor(en) / Beteiligte

• Sánchez Barrueco, Alvaro
• González Galán, Fernando
• Villacampa Aubá, José Miguel
• Díaz Tapia, Gonzalo
• Fernández Hernández, Sofía
• Martín-Arriscado Arroba, Cristina
• Cenjor Español, Carlos
• Almodóvar Álvarez, Carlos

Titel

p16 Influence on Laryngeal Squamous Cell Carcinoma Relapse and Survival

Ist Teil von

• Otolaryngology-head and neck surgery, 2019-06, Vol.160 (6), p.1042-1047

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2019

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objective (1) To identify p16 protein in laryngeal squamous cell carcinoma (LSCC) specimens and to correlate it with the presence of human papillomavirus (HPV) found in these specimens from a previous study. (2) To analyze p16 impact on 10-year overall and disease-free survival. Study Design Retrospective case series with oncologic database chart review. Setting Academic tertiary care hospital. Subjects A total of 123 samples of LSCC (taken from the glottis only) from patients treated with primary surgical resection between 1977 and 2005. Methods p16 protein expression was analyzed through immunohistochemistry and compared with the presence of HPV established in our previous studies. Results were compared with histologic, clinicopathologic, and survival parameters, with a 10-year follow-up. Results Of the samples, 39.02% were positive for p16, but only 11.38% were positive for both p16 and HPV. The p16+ cohort showed a significant improvement in disease-free survival (P = .0022); statistical significance was not achieved for overall survival. p16+ cases had fewer relapses over time, with no relapses after a 2-year follow-up. Age at the time of diagnosis and tobacco consumption were the only epidemiologic factors that influenced overall survival. Conclusion The expression of p16 protein was a beneficial prognostic factor for disease-free survival among patients with LSCC of the glottis, with no relapses after a 2-year follow-up.