Details

Autor(en) / Beteiligte

• Liang, Weibin
• Xu, Huoshu
• Carraro, Francesco
• Maddigan, Natasha K
• Li, Qiaowei
• Bell, Stephen G
• Huang, David M
• Tarzia, Andrew
• Solomon, Marcello B
• Amenitsch, Heinz
• Vaccari, Lisa
• Sumby, Christopher J
• Falcaro, Paolo
• Doonan, Christian J

Titel

Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal–Organic Frameworks

Ist Teil von

• Journal of the American Chemical Society, 2019-02, Vol.141 (6), p.2348-2355

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Encapsulation of biomacromolecules in metal–organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.