Details

Autor(en) / Beteiligte

• Rofael, Sylvia A D
• McHugh, Timothy D
• Troughton, Rachael
• Beckmann, Joanne
• Spratt, David
• Marlow, Neil
• Hurst, John R

Titel

Airway microbiome in adult survivors of extremely preterm birth: the EPICure study

Ist Teil von

• The European respiratory journal, 2019-01, Vol.53 (1), p.1801225

Ort / Verlag

England

Erscheinungsjahr

2019

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth that leads to lifelong respiratory morbidity. The EPICure study has investigated the longitudinal health outcomes of infants born extremely preterm (EP; <26 weeks gestation). Our aim was to characterise the airway microbiome in young adults born extremely preterm, with and without neonatal BPD, in comparison to matched term-born controls.Induced sputum was collected from 92 young adults aged 19 years (51 EP and 41 controls). Typical respiratory pathogens were detected using quantitative PCR. 16S rRNA gene sequencing was completed on 74 samples (29 EP with BPD; 9 EP without BPD; and 36 controls).The preterm group with BPD had the least diverse bacterial communities. The relative abundance of Bacteriodetes, particularly was significantly lower in the preterm group compared to controls. This decline was balanced by a nonsignificant increase in Firmicutes Total relative abundance correlated with forced expiratory volume in 1 s z-score (ρ=0.272; p<0.05). Typical respiratory pathogen loads and prevalence were similar between groups.In conclusion extremely preterm birth is associated with a significant dysbiosis in airway microbiome in young adulthood regardless of neonatal BPD status. This is characterised by a shift in the community composition away from Bacteriodetes as manifested in a significant drop in relative abundance.