Details

Autor(en) / Beteiligte

• Valencia-Sanchez, Cristina
• Steenerson, Kristen K.
• Kelemen, Katalin
• Orenstein, Robert
• Kusne, Shimon
• Grill, Marie F.

Titel

Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis

Ist Teil von

• Journal of neurovirology, 2019-04, Vol.25 (2), p.280-283

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.