Details

Autor(en) / Beteiligte

• Lee, Sunghoon
• Sasaki, Daisuke
• Kim, Dongmin
• Mori, Mami
• Yokota, Tomoyuki
• Lee, Hyunjae
• Park, Sungjun
• Fukuda, Kenjiro
• Sekino, Masaki
• Matsuura, Katsuhisa
• Shimizu, Tatsuya
• Someya, Takao

Titel

Ultrasoft electronics to monitor dynamically pulsing cardiomyocytes

Ist Teil von

• Nature nanotechnology, 2019-02, Vol.14 (2), p.156-160

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In biointegrated electronics, the facile control of mechanical properties such as softness and stretchability in electronic devices is necessary to minimize the perturbation of motions inherent in biological systems . For in vitro studies, multielectrode-embedded dishes and other rigid devices have been widely used. Soft or flexible electronics on plastic or elastomeric substrates offer promising new advantages such as decreasing physical stress and/or applying mechanical stimuli . Recently, owing to the introduction of macroporous plastic substrates with nanofibre scaffolds , three-dimensional electrophysiological mapping of cardiomyocytes has been demonstrated. However, quantitatively monitoring cells that exhibit significant dynamical motions via electric probes over a long period without affecting their natural motion remains a challenge. Here, we present ultrasoft electronics with nanomeshes that monitor the field potential of human induced pluripotent stem cell-derived cardiomyocytes on a hydrogel, while enabling them to move dynamically without interference. Owing to the extraordinary softness of the nanomeshes, nanomesh-attached cardiomyocytes exhibit contraction and relaxation motions comparable to that of cardiomyocytes without attached nanomeshes. Our multilayered nanomesh devices maintain reliable operations in a liquid environment, enabling the recording of field potentials of the cardiomyocytes over a period of 96 h without significant degradation of the nanomesh devices or damage of the cardiomyocytes.