Details

Autor(en) / Beteiligte

• Sánchez-Fructuoso, Ana I.
• Pérez-Flores, Isabel
• Del Río, Francisco
• Blázquez, Jesús
• Calvo, Natividad
• Moreno de la Higuera, Maria Á.
• Gómez, Angel
• Alonso-Lera, Santiago
• Soria, Ana
• González, Manuel
• Corral, Ervigio
• Mateos, Alonso
• Moreno-Sierra, Jesús
• Fernández Pérez, Cristina

Titel

Uncontrolled donation after circulatory death: A cohort study of data from a long-standing deceased-donor kidney transplantation program

Ist Teil von

• American journal of transplantation, 2019-06, Vol.19 (6), p.1693-1707

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Despite good long-term outcomes of kidney transplants from controlled donation after circulatory death (DCD) donors, there are few uncontrolled DCD (uDCD) programs. This longitudinal study compares outcomes for all uDCD (N = 774) and all donation after brain death (DBD) (N = 613) kidney transplants performed from 1996 to 2015 at our center. DBD transplants were divided into those from standard-criteria (SCD) (N = 366) and expanded-criteria (N = 247) brain-dead donors (ECD). One-, 5-, and 10-year graft survival rates were 91.7%, 85.7%, and 80.6% for SCD; 86.0%, 75.8%, and 61.4% for ECD; and 85.1%, 78.1%, and 72.2% for uDCD, respectively. Graft survival was worse in recipients of uDCD kidneys than of SCD (P = .004) but better than in transplants from ECD (P = .021). The main cause of graft loss in the uDCD transplants was primary nonfunction. Through logistic regression, donor death due to pulmonary embolism (OR 4.31, 95% CI 1.65-11.23), extrahospital CPR time ≥75 minutes (OR1.94, 95%CI 1.18-3.22), and in-hospital CPR time ≥50 minutes (OR 1.79, 95% CI 1.09-2.93) emerged as predictive factors of primary nonunction. According to the outcomes of our long-standing kidney transplantation program, uDCD could help expand the kidney donor pool.