Details

Autor(en) / Beteiligte

• Li, De-Feng
• Gu, Yan
• Zhang, Jing-Ru
• Liu, Kun
• Zhao, Li-Ming

Titel

Diastereoselective Construction of Spiro-furo[3,2- c]benzopyranoxindoles through a Cu(OTf) 2 /AcOH Cooperative Promoted Bicyclization Reaction

Ist Teil von

• Journal of organic chemistry, 2019-01, Vol.84 (2), p.879-887

Ort / Verlag

United States

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We disclose herein a highly diastereoselective approach for the Cu(OTf) /AcOH cooperative promoted bicyclization reaction of 3-cinnamyl-3-hydroxy-2-oxindoles and ortho-quinonemethides ( o-QMs) generated in situ from salicylaldehydes for the synthesis of spiro-furo[3,2- c]benzopyranoxindoles. The reaction has the advantages of readily available starting materials, simple operation, and high bond-forming efficiency, which not only provides an efficient access to spiro-furo[3,2- c]benzopyranoxindoles but also enriches the research contents of o-QMs-involved reactions. The synthetic applications of the products such as amide reduction are also demonstrated.