Details

Autor(en) / Beteiligte

• Gupta, Piyush B.
• Pastushenko, Ievgenia
• Skibinski, Adam
• Blanpain, Cedric
• Kuperwasser, Charlotte

Titel

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

Ist Teil von

• Cell stem cell, 2019-01, Vol.24 (1), p.65-78

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness, this process inherently carries the risk of cancer initiation. Consequently, recent research suggests phenotypic plasticity as a new paradigm for understanding cancer initiation, progression, and resistance to therapy. Here, we discuss how cells acquire plasticity and the role of plasticity in initiating cancer, cancer progression, and metastasis and in developing therapy resistance. We also highlight the epithelial-to-mesenchymal transition (EMT) and known molecular mechanisms underlying plasticity and we consider potential therapeutic avenues. Gupta et al. discuss how cells acquire plasticity and the role of plasticity in initiating cancer, cancer progression, and metastasis and in developing therapy resistance. The article also highlights the epithelial-to-mesenchymal transition (EMT) and known molecular mechanisms underlying plasticity, and it considers potential therapeutic avenues.