Details

Autor(en) / Beteiligte

• Chovanec, Michal
• Cheng, Liang

Titel

Molecular characterization of testicular germ cell tumors: chasing the underlying pathways

Ist Teil von

• Future oncology (London, England), 2019-01, Vol.15 (3), p.227-229

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2019

Link zum Volltext

Beschreibungen/Notizen

• The overall median frequency of mutations was 0.5/Mb, which is in contrast to overall mutation rate of other cancers such as melanoma (14.4/Mb) (15), colorectal cancer (9.9-11.6/Mb) (16) or lung cancer (7.2/Mb) (17). High-mutational burden is a well-established predictive biomarker for checkpoint inhibition in several cancers (18); however, the scarcity of mutations in testicular cancer suggests a low probability to achieve a treatment effect with such agents. The methylation patterns in nonseminoma were consistent with silencing of important tumor-suppressor genes such as BRCA1, RAD51C, MGMT and RASSF1A (all involved in DNA repair pathways). Landscape of tumor mutation load, mismatch repair deficiency, and PD-L1 expression in a large patient cohort of gastrointestinal cancers.