Details

Autor(en) / Beteiligte

• Scheidt, Felix
• Neufeld, Jessica
• Schäfer, Michael
• Thiehoff, Christian
• Gilmour, Ryan

Titel

Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

Ist Teil von

• Organic letters, 2018-12, Vol.20 (24), p.8073-8076

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A geminal difluorination of alkenes based on I­(I)/I­(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-TolI as the organocatalyst, turnover is enabled by Selectfluor-mediated oxidation to generate the ArIF2 species in situ. Extension to include α-substituted styrenes bearing fluorine-containing groups is disclosed and provides an expansive platform for the generation of fluorine-rich architectures.