Digestive and liver disease, 2019-04, Vol.51 (4), p.516-523
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Salivary markers of hepato-metabolic comorbidities in pediatric obesity
- Ist Teil von
- Digestive and liver disease, 2019-04, Vol.51 (4), p.516-523
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2019
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- The pediatric obesity epidemic calls for the noninvasive detection of individuals at higher risk of complications. To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease. Medical history, clinical, anthropometric, and laboratory data including serum triglyceride, glucose, insulin, HOMA, HDL-cholesterol, and UA levels of 23 obese children (15 with [St+] and 8 without [St−] ultrasonographic hepatic steatosis) and 18 normal weight controls were considered. Serum and salivary UA (p < 0.05; R2 = 0.51), insulin (p < 0.0001; R2 = 0.79), and HOMA (p < 0.0001; R2 = 0.79) levels were significantly correlated; however their values tended to be only slightly higher in the obese patients, predominately in [St+], than in the controls. Notably, UA and insulin levels in both fluids increased in parallel to the number of MetS components. After conversion of the z-logit function including salivary/anthropometric parameters in a stepwise logistic regression analysis, a factor of 0.5 allowed for predicting hepatic steatosis with high sensitivity, specificity, and total accuracy. Salivary testing together with selected anthropometric parameters helps to identify noninvasively obese children with hepatic steatosis and/or having MetS components.