Details

Autor(en) / Beteiligte

• Vaughn, Caila B
• Kavak, Katelyn S
• Dwyer, Michael G
• Bushra, Aisha
• Nadeem, Muhammad
• Cookfair, Diane L
• Ramanathan, Murali
• Benedict, Ralph HB
• Zivadinov, Robert
• Goodman, Andrew
• Krupp, Lauren
• Motl, Robert W
• Weinstock-Guttman, Bianca
• Kolb, Channa
• Robb, Jessica F.
• Jubelt, Burk
• Gerber, Allen
• Kister, Ilya
• Ryerson, Lana Zhovtis
• Coyle, Patricia
• Perel, Allan
• Gottesman, Malcolm
• Lenihan, Michael
• Edwards, Keith
• Garten, Lore
• Picone, Mary Ann

Titel

Fatigue at enrollment predicts EDSS worsening in the New York State Multiple Sclerosis Consortium

Ist Teil von

• Multiple sclerosis, 2020-01, Vol.26 (1), p.99-108

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background: Fatigue is one of the most common and distressing symptoms among persons with multiple sclerosis (pwMS). Objective: The aim of this study is to evaluate fatigue as a predictor for disease worsening among pwMS. Methods: In this retrospective cohort study of New York State MS Consortium (NYSMSC) registry, MS patients reporting moderate-to-severe fatigue at study enrollment (n = 2714) were frequency matched to less-fatigued subjects (n = 2714) on age, baseline Kurtzke Expanded Disability Status Scale (EDSS), disease duration, and MS phenotype. Change from baseline patient-reported outcomes (PROs), as measured by LIFEware™, categorized participants into two groups: those with stable/improved outcomes and those who worsened. In a subgroup of patients with longitudinal data (n = 1951), sustained EDSS worsening was analyzed using Cox proportional hazards modeling to explore the effect of fatigue. Results: The median survival time from study enrollment to sustained EDSS worsening was 8.7 years (CI: 7.2–10.1). Participants who reported fatigue at baseline were more likely to experience sustained EDSS worsening during follow-up (HR: 1.4, 95% CI: 1.2–1.7). Patients who were fatigued at baseline were also more likely to report worsening psychosocial limitations (all ps ⩽ 0.01). Conclusion: In addition to being a common symptom of MS, severe fatigue was a significant predictor for EDSS worsening in the NYSMSC.