Details

Autor(en) / Beteiligte

• Kalel, Vishal C
• Mäser, Pascal
• Sattler, Michael
• Erdmann, Ralf
• Popowicz, Grzegorz M

Titel

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Ist Teil von

• Current opinion in microbiology, 2018-12, Vol.46, p.116-122

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids’ glycosomal transport components as targets for new trypanocidal therapies.