Details

Autor(en) / Beteiligte

• Romero‐Ramírez, Sandra
• Navarro‐Hernandez, Itze C.
• Cervantes‐Díaz, Rodrigo
• Sosa‐Hernández, Víctor A.
• Acevedo‐Ochoa, Ernesto
• Kleinberg‐Bild, Ari
• Valle‐Rios, Ricardo
• Meza‐Sánchez, David E.
• Hernández‐Hernández, José M.
• Maravillas‐Montero, José L.

Titel

Innate‐like B cell subsets during immune responses: Beyond antibody production

Ist Teil von

• Journal of leukocyte biology, 2019-05, Vol.105 (5), p.843-856

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• B lymphocytes are recognized for their crucial role in the adaptive immunity since they represent the only leukocyte lineage capable of differentiating into Ab‐secreting cells. However, it has been demonstrated that these lymphocytes can exert several Ab‐independent functions, including engulfing and processing Ags for presentation to T cells, secreting soluble mediators, providing co‐stimulatory signals, and even participating in lymphoid tissues development. Beyond that, several reports claiming the existence of multiple B cell subsets contributing directly to innate immune responses have appeared. These “innate‐like” B lymphocytes, whose phenotype, development pathways, tissue distribution, and functions are in most cases notoriously different from those of conventional B cells, are crucial to early protective responses against pathogens by exerting “crossover” defensive strategies that blur the established boundaries of innate and adaptive branches of immunity. Examples of these mechanisms include the rapid secretion of the polyspecific natural Abs, increased susceptibility to innate receptors‐mediated activation, cytokine secretion, downstream priming of other innate cells, usage of specific variable immunoglobulin gene‐segments, and other features. As these new insights emerge, it is becoming preponderant to redefine the functionality of B cells beyond their classical adaptive‐immune tasks. Beyond conventional populations, B cell compartment comprises several subsets developing “innate‐like” functions, implicated in early protection against pathogens mediated by different mechanisms besides antibody secretion.