Bone marrow transplantation (Basingstoke), 2009-12, Vol.44 (11), p.739-748
2009
Details
- Autor(en) / Beteiligte
- Titel
- Therapy with mycophenolate mofetil for refractory acute and chronic GVHD
- Ist Teil von
- Bone marrow transplantation (Basingstoke), 2009-12, Vol.44 (11), p.739-748
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- We evaluated the pharmacokinetics and efficacy of oral mycophenolate mofetil (MMF) for treatment of refractory GVHD. In a prospective study of acute GVHD, 9 of 19 patients (47%) had a response and 10 (53%) had no improvement. Survival at 6 and 12 months after the start of MMF was 37 and 16%, respectively. In a retrospective study of acute GVHD, 14 of 29 patients (48%) had a response and 15 (52%) had no improvement. Survival at 6 and 12 months was 55 and 52%, respectively. In a prospective study of chronic GVHD, the cumulative incidence of disease resolution and withdrawal of all systemic immunosuppressive treatment was 9, 17 and 26% at 12, 24 and 36 months, respectively, after starting MMF. Thirteen patients (59%) required additional systemic immunosuppressive treatment for chronic GVHD. Nine of the 42 patients (21%) in the prospective studies discontinued MMF treatment because of toxicity. The area under the curve plasma concentrations of mycophenolic acid seemed to be suboptimal among patients with acute GVHD but not among those with chronic GVHD. MMF can be used effectively for treatment of GVHD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0268-3369eISSN: 1476-5365DOI: 10.1038/bmt.2009.76Titel-ID: cdi_proquest_miscellaneous_21328431
- Format
- –
- Schlagworte
- Administration, Oral, Adolescent, Adult, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Biological and medical sciences, Bone marrow, stem cells transplantation. Graft versus host reaction, Child, Child, Preschool, Complications and side effects, Dosage and administration, Drug therapy, Female, Graft versus host reaction, Graft vs Host Disease - blood, Graft vs Host Disease - drug therapy, Graft vs Host Disease - metabolism, Hematopoietic stem cells, Humans, Immunomodulators, Immunosuppressive Agents - blood, Immunosuppressive Agents - pharmacokinetics, Immunosuppressive Agents - therapeutic use, Male, Medical sciences, Middle Aged, Mycophenolate mofetil, Mycophenolic acid, Mycophenolic Acid - analogs & derivatives, Mycophenolic Acid - blood, Mycophenolic Acid - pharmacokinetics, Mycophenolic Acid - therapeutic use, Patients, Pharmacokinetics, Pharmacology. Drug treatments, Prospective Studies, Retrospective Studies, Risk factors, Stem cell transplantation, Survival, Toxicity, Transfusions. Complications. Transfusion reactions. Cell and gene therapy, Transplantation, Treatment Outcome, Young Adult