Details

Autor(en) / Beteiligte

• Chang, Joseph
• Breshears, Jonathan D.
• Molinaro, Annette M.
• Sneed, Penny K.
• McDermott, Michael W.
• Theodosopoulos, Philip V.
• Tward, Aaron D.

Titel

Impact of pretreatment growth on Tumor control for vestibular schwannomas following gamma knife

Ist Teil von

• The Laryngoscope, 2019-03, Vol.129 (3), p.743-747

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Objectives/Hypothesis To determine if volumetric growth prior to gamma knife (GK) radiosurgery predicts long‐term tumor control. Study Design Retrospective cohort study. Methods Sporadic vestibular schwannomas (VS) treated with GK between 2002 and 2014 at a single tertiary care center were identified. Patients were included if they had over 6 months of pretreatment observation and over 1.5 years of posttreatment follow‐up. Volumetric tumor analysis was performed on T1 postcontrast imaging. Pretreatment and posttreatment volume change was calculated. Tumors with over 20% volume increase were classified as growing. Results There were 62 patients included in this study; 48 had pretreatment growth and 14 had no pretreatment growth. Median tumor volume was 0.58 ± 1.8 cm3 and median follow‐up was 3.3 ± 2.0 years. For tumors with and without pretreatment growth, salvage treatment rates were 2% and 7% (P = .35), and posttreatment radiologic stability rates were 73% and 86%, respectively (P = .33). Median pretreatment growth was 27 ± 33% per year for tumors with posttreatment radiographic growth and 18 ± 26% per year for tumors without posttreatment radiographic growth (P = .99). Conclusions Pretreatment growth was not associated with increased salvage treatment or posttreatment radiographic progression rates in VS following GK. Level of Evidence 4 Laryngoscope, 129:743–747, 2019