Details

Autor(en) / Beteiligte

• Lim, Ji Hyae
• Lee, Bom Yi
• Kim, Jin Woo
• Han, You Jung
• Kim, Min Hyoung
• Chung, Jin Hoon
• Han, Jung Yeol
• Kim, Moon Young
• Ryu, Hyun Mee

Titel

Effective Fetal Epigenetic Biomarkers for Noninvasive Fetal Trisomy 21 Detections

Ist Teil von

• Fetal diagnosis and therapy, 2019-08, Vol.46 (2), p.133-138

Ort / Verlag

Basel, Switzerland: S. Karger AG

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Introduction: Recently, we identified three novel fetal-specific epigenetic DNA regions (FSERs) on chromosome 21 for detection of noninvasive fetal trisomy 21 (T21). In this study, the diagnostic accuracies of the three FSERs were assessed on a larger panel of the first-trimester pregnant women. Material and Methods: This study was conducted with maternal plasma collected from 167 pregnant women carrying 155 chromosomally normal and 12 T21 fetuses (10–13 gestational weeks). Accuracies of FSERs for noninvasive prenatal test of fetal T21 were estimated by the area under the receiver operator characteristic curve (AUC). Results: The levels of all FSERs increased in pregnant women with T21 fetuses when compared with controls (p < 0.001 for all). The levels of the three FSERs did not differ according to maternal age, body mass index, and fetal sex at maternal blood sampling (p > 0.05 for all). In noninvasive fetal T21 detection, the AUC of FSER1, FSER2, and FSER3 were 0.859 (95% CI: 0.746–0.972), 0.919 (95% CI: 0.856–0.982), and 0.868 (95% CI: 0.746–0.990), respectively. Discussion: The findings of this study suggest that all FSERs may be useful for noninvasive fetal T21 detection, regardless of maternal age, body mass index, and fetal sex.