Details

Autor(en) / Beteiligte

• Al-Yassin, Ghassan A
• Bretscher, Peter A

Titel

Does T Cell Activation Require a Quorum of Lymphocytes?

Ist Teil von

• The Journal of immunology (1950), 2018-11, Vol.201 (10), p.2855-2861

Ort / Verlag

United States

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek

Beschreibungen/Notizen

• Recent reports suggest a quorum of T cells is required to activate T lymphocytes and that this requirement may help explain why scarce lymphocytes, specific for peripheral self-antigen, are rarely activated by Ag. This proposal runs counter to the commonly held framework that the Ag-dependent, but CD4 T lymphocyte-independent, activation of CD8 T lymphocytes, and the activation of CD4 T lymphocytes themselves, can occur when a single CD8 or CD4 T lymphocyte encounters Ag under appropriately dangerous circumstances. We argue that a review of older literature often ignored, as well as of contemporary studies, supports the quorum concept and is difficult to reconcile with the Danger Model.