Details

Autor(en) / Beteiligte

• Chang, Y
• Dong, X S
• Li, J
• Zhang, X Z
• Yan, H
• Zhang, W
• Zhao, L
• Zuo, Y H
• Yu, Y B
• Dou, Y L
• Feng, J J
• Han, F

Titel

Predictive value of typical cataplexy+ DQB10602 positive to hypocretin-1 reduction in cerebrospinal fluid in patients with narcolepsy

Ist Teil von

• Zhong hua yi xue za zhi, 2018-10, Vol.98 (40), p.3253-3257

Ort / Verlag

China

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To discusses the predictive value of typical cataplexy+ HLA-DQB1*0602 positive to hypocretin-1 (HCRT-1) reduction in cerebrospinal fluid (CSF) in patients with narcolepsy. A total of 165 narcoleptic patients, who were diagnosed at the Sleep Center of Peking University People's Hospital and Peking University International Hospital from March 2003 to March 2017, were recruited. The CSF HCRT-1 level and DQB1*0602 were measured in all the subjects. The narcoleptic patients were divided into two groups: typical cataplexy+ DQB1*0602 positive were CH group, and others who were not typical cataplexy and DQB1*0602 positive simultaneously were NCH group. The HCRT-1 level in CSF was declared to have a serious reduction when HCRT-1≤110 ng/L. According to this standard, the CH group and NCH group were subdivided into sub-groups and the data was analyzed to investigate the predictive value of typical cataplexy+ HLA-DQB1*0602 positive to HCRT-1 reduction. There were 142 patients in CH group, including 137 patients with HCRT