Details

Autor(en) / Beteiligte

• García-Ortega, Alberto
• Mañas, Eva
• López-Reyes, Raquel
• Selma, María José
• García-Sánchez, Aldara
• Oscullo, Grace
• Jiménez, David
• Martínez-García, Miguel Ángel

Titel

Obstructive sleep apnoea and venous thromboembolism: pathophysiological links and clinical implications

Ist Teil von

• The European respiratory journal, 2019-02, Vol.53 (2), p.1800893

Ort / Verlag

England

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Obstructive sleep apnoea (OSA) and pulmonary embolism (PE) remain major health issues worldwide. Data from pathophysiological studies suggest that both intermittent hypoxia and sleep fragmentation are associated with increased blood coagulability, endothelial dysfunction and venous stasis. There is growing evidence that OSA is potentially prevalent in and a risk factor for PE. Conversely, patients with acute PE have two to four times greater risk of moderate-to-severe OSA. The role of continuous positive airway pressure (CPAP) treatment in improving clinically meaningful outcomes in PE patients remains unclear, although some authors have suggested that CPAP could improve the hypercoagulability state and normalise circadian alterations in some of the coagulation molecules, as observed in patients with OSA. Emerging research highlights the complex interdependent relationships between OSA and PE, emphasising the need for rigorous, well-powered trials that address the impact of OSA and its treatment on the prevention and management of PE. Undoubtedly, these will require closer collaboration between the sleep medicine and clinical/venous thromboembolism communities.