Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1233-1236
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Novel small molecule bradykinin B sub(1) receptor antagonists. Part 3: Hydroxyurea derivatives
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1233-1236
- Erscheinungsjahr
- 2010
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Hydroxy urea moieties are introduced as a new class of bradykinin B sub(1) receptor antagonists. First, the SAR of the lead compound was systematically explored. Subsequent optimization resulted in the identification of several biaryl-based hydroxyurea bradykinin B sub(1) receptor antagonists with low-nanomolar activity and very high oral bioavailability in the rat.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XDOI: 10.1016/j.bmcl.2009.11.121Titel-ID: cdi_proquest_miscellaneous_21281552
- Format
- –