Details

Autor(en) / Beteiligte

• Timm, Stephan
• Otto, Christoph
• Begrich, Daniel
• Illert, Bertram
• Hamelmann, Wulf
• Ulrichs, Karin
• Thiede, Arnulf
• Timmermann, Wolfgang

Titel

Short-term immunosuppression after rat parathyroid allotransplantation

Ist Teil von

• Microsurgery, 2003-10, Vol.23 (5), p.503-507

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2003

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of this study was to evaluate whether short‐term postoperative immunosuppression is able to sufficiently prolong graft survival after experimental allogeneic parathyroid transplantation. Heterotopic parathyroid transplantation was performed in 6 groups: 1) syngeneic control Lewis (LEW) to LEW; 2) allogeneic control Wistar‐Furth (WF) to LEW; 3–5) WF to LEW plus short‐term immunosuppression, postoperative days 1–13 (cyclosporine 5/10/20 mg/kg); and 6) WF to LEW plus 10 mg/kg CyA from preoperative day 7 to postoperative day 7. Graft function was examined up to 60 days; histological and immunohistological examination was performed on all grafts with impaired function. Graft function after syngeneic transplantation was indefinite, while recipients of allogeneic grafts turned hypocalcemic after 13 ± 2 days. With immunosuppression, graft function was 21 ± 2 days (groups 5 and 6) and 28 ± 3 days (groups 3 and 4). Histologically, a cellular infiltrate responsible for graft destruction was found. The results show that indefinite parathyroid allograft survival cannot be achieved by short‐term immunosuppression alone. Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:503–507 2003