Details

Autor(en) / Beteiligte

• Grafft, Carrie A
• Cornell, Lynn D
• Gloor, James M
• Cosio, Fernando G
• Gandhi, Manish J
• Dean, Patrick G
• Stegall, Mark D
• Amer, Hatem

Titel

Antibody-mediated rejection following transplantation from anHLA-identical sibling

Ist Teil von

• Nephrology, dialysis, transplantation, 2010-01, Vol.25 (1), p.307-310

Erscheinungsjahr

2010

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Putative antibody-mediated rejection (AMR) in HLA-identical sibling transplantation has rarely been reported and occurred before routine calcineurin inhibitor use. A 29-year-old male developed allograft dysfunction following an HLA-identical renal transplant from his sibling. A pretransplant panel-reactive antibody (PRA) was elevated, pre-transplant crossmatch was negative and no donor-specific antibody (DSA) was identified. Induction with alemtuzumab was followed by maintenance immunosuppression with corticosteroids, tacrolimus and mycophenolate. A biopsy for allograft dysfunction suggested AMR, but DSA could not be detected. Treatment for rejection was transiently successful. Undetectable minor histocompatibility antibodies may have contributed.