Details

Autor(en) / Beteiligte

• La Joie, Renaud
• Ayakta, Nagehan
• Seeley, William W.
• Borys, Ewa
• Boxer, Adam L.
• DeCarli, Charles
• Doré, Vincent
• Grinberg, Lea T.
• Huang, Eric
• Hwang, Ji-Hye
• Ikonomovic, Milos D.
• Jack, Clifford
• Jagust, William J.
• Jin, Lee-Way
• Klunk, William E.
• Kofler, Julia
• Lesman-Segev, Orit H.
• Lockhart, Samuel N.
• Lowe, Val J.
• Masters, Colin L.
• Mathis, Chester A.
• McLean, Catriona L.
• Miller, Bruce L.
• Mungas, Daniel
• O'Neil, James P.
• Olichney, John M.
• Parisi, Joseph E.
• Petersen, Ronald C.
• Rosen, Howard J.
• Rowe, Christopher C.
• Spina, Salvatore
• Vemuri, Prashanthi
• Villemagne, Victor L.
• Murray, Melissa E.
• Rabinovici, Gil D.

Titel

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

Ist Teil von

• Alzheimer's & dementia, 2019-02, Vol.15 (2), p.205-216

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB–positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification. Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings. CL values increased with each CERAD neuritic plaque score increment (median −3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET-pathology associations were comparable across sites and unchanged when restricting the analyses to the 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%). Our study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds.