Details

Autor(en) / Beteiligte

• Zhang, Jiabin
• Chen, Congcong
• Gadi, Madhusudhan Reddy
• Gibbons, Christopher
• Guo, Yuxi
• Cao, Xuefeng
• Edmunds, Garrett
• Wang, Shuaishuai
• Liu, Ding
• Yu, Jin
• Wen, Liuqing
• Wang, Peng G.

Titel

Machine‐Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer

Ist Teil von

• Angewandte Chemie (International ed.), 2018-12, Vol.57 (51), p.16638-16642

Ort / Verlag

Germany

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• For decades, researchers have endeavored to develop a general automated system to synthesize oligosaccharides that is comparable to the preparation of oligonucleotides and oligopeptides by commercially available machines. Inspired by the success of automated oligosaccharide synthesis through chemical glycosylation, a fully automated system is reported for oligosaccharides synthesis through enzymatic glycosylation in aqueous solution. The designed system is based on the use of a thermosensitive polymer and a commercially available peptide synthesizer. This study represents a proof‐of‐concept demonstration that the enzymatic synthesis of oligosaccharides can be achieved in an automated manner using a commercially available peptide synthesizer. Sugar synthesis in solution: An automated system is designed for oligosaccharide synthesis. The automated process is based on enzymatic glycosylation and the use of a thermosensitive polymer and a commercially available peptide synthesizer.