Details

Autor(en) / Beteiligte

• Gumina, S.
• Candela, V.
• Castagna, A.
• Carnovale, M.
• Passaretti, D.
• Venditto, T.
• Giannicola, G.
• Villani, C.

Titel

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity

Ist Teil von

• Musculoskeletal surgery, 2018-10, Vol.102 (Suppl 1), p.35-40

Ort / Verlag

Milan: Springer Milan

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC. Methods Peripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41–65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics. Results The prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59–2.53, p  > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°–165°)] and 16 [flexion 82.5° (range 50°–95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005–3.482, p  < 0.05). Conclusions Apo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC. Level of Evidence III.